The modern era

 The 16th century was marked by the outbreak of the Plague, a boom in the regional textile industry, and the Protestant  revolts.

The first Calvinists appeared in the area in 1542; by 1555 anti-Protestant repression was taking place. In 1578, the Hurlus, a group of Protestant rebels, stormed the castle of the Counts of Mouscron. They were removed four months later by a Catholic Wallon regiment, after which they tried several times between 1581 and 1582 to take the city of Lille, all in vain. The Hurlus were notably held back by the legendary Jeanne Maillotte. At the same time (1581), at the call of Elizabeth I of England, the north of the Southern Netherlands, having gained a Protestant majority, successfully revolted and formed the United Provinces.

In 1667, Louis XIV of France (the Sun-King) successfully laid siege to Lille, resulting in it becoming French in 1668 under the Treaty of Aix-la-Chapelle, provoking discontent among the citizens of the prosperous city. A number of important public works undertaken between 1667 and 1670, such as the Citadel (erected by Vauban), or the creation of the quartiers of Saint-André and la Madeleine, enabled the King to gradually gain the confidence of his Lille subjects, some of whom continued to feel Flemish, though they had always spoken the Latin Picard language.
Entrance to the 'Vauban Citadel' (17th century)

For five years, from 1708 to 1713, the city was occupied by the Dutch, during the War of the Spanish Succession. Throughout the 18th century, Lille remained profoundly Catholic. It took little part in the French Revolution, though there were riots and the destruction of churches. In 1790, the city held its first municipal elections.